Induction of expressions of HLA class I and class II antigens by interferon on human renal cell carcinoma or bladder cancer cell lines

Interferon-induced expressions of HLA class I and class II (DR, DP, DQ) antigens on human renal cell carcinoma (RCC) cell lines and bladder cancer cell lines were analyzed by flowcytometry. Class I antigen was present on all six different RCC cell lines and the expression was enhanced with IFN-γ treatment except one cell line, Caki-2. Although no RCC cell lines expressed class II antigens without IFN-γ treatment, the treatment induced the expression of DR antigen in all cell lines except Caki-2. DP antigen was induced on KPK-1 and KPK-13 with exposure to IFN-γ. On the other hand, bladder cancer cell lines studied showed surface expression of class I antigen and enhanced expression of class I antigen with IFN-γ treatment. However, IFN-γ didn't enhance the expression of class II antigens on any of those bladder cancer cell lines. The minimum concentrations of IFN-γ to increase the expression of class I and DR andtigens on both KPK-13 and ACHN were 4 IU/ml and 100 IU/ml, respectively. The incubation time with IFN-γ to get the maximal expression of class I and DR antigens on KPK-13 were 36 hr and 48 hr, respectively. Meanwhile, although the expression of class I antigen on RCC cell lines was enhanced by IFN-α, IFN-α could not give any effect in class II antigens. Our results demonstrate the obvious effect of IFN-γ to enhance the expression of not only HLA class I antigen but also class II antigens on RCC cell lines

A propensity score matching study on robot-assisted radical cystectomy for older patients : comparison of intracorporeal ileal conduit and cutaneous ureterostomy

Background: Robot-assisted radical cystectomy (RARC) and intracorporeal urinary diversion are less invasive than conventional procedures. However, for older patients, cutaneous ureterostomy (CUS) may be preferred because urinary diversion using the intestine has a high incidence of perioperative complications and is highly invasive. The purpose of this study was to demonstrate the safety and efficacy of intracorporeal ileal conduit (ICIC) compared with CUS in patients aged 75 years or older who underwent RARC. Methods: From October 2014 to December 2021, 82 patients aged 75 years or older who underwent RARC at Tokushima University Hospital, Tokushima Prefectural Central Hospital, or Ehime Prefectural Central Hospital were retrospectively reviewed. Of these, 52 and 25 patients who underwent ICIC and CUS, respectively, were included. After adjusting the patients’ characteristics using propensity score-matching, surgical results and prognoses were retrospectively compared. The propensity score was based on age, Eastern Cooperative Oncology Group Performance Status Scale (ECOG-PS), American Society of Anesthesiologists physical status classification (ASA-PS), clinical tumor stage, and neoadjuvant chemotherapy. Results: The median age was lower in the ICIC group compared with the CUS group, and the proportion of high-risk cases (ECOG-PS ≥ 2 or ASA-PS ≥ 3) did not differ. The median operation time was longer in the ICIC group, and estimated blood loss was higher, compared with the CUS group. There were no significant differences in the incidence of complications within the first 30 postoperative days, incidence of complications 30–90 days after surgery, 2 year overall survival, 2-year cancer-specific survival, and 2-year recurrence-free survival. The stent-free rate was significantly lower in the CUS group than that in the ICIC group. Conclusion: In older patients, the ICIC group showed non-inferior surgical and oncological outcomes compared with the CUS group. Urinary diversion following RARC in older patients should be carefully selected by considering not only the age but also the general condition (including comorbidities) of the patient

An obscure case of chronic unilateral hematuria bleeding point

Chronic unilateral hematuria due to hemangioma of the renal papilla is endoscopically treatable. Hemangiomas of the renal papilla are usually located at the tip of the renal papilla. However in this case, the hemangioma was not located at the tip of the renal papilla, forcing the patient to exercise until just before surgery and to keep the renal pelvic pressure low to identify the hemangioma

Representative Physical Properties for the Vapor Boundary Layer in the Case of Laminar Film Condensation of Binary Vapor Mixtures : (II) Free-Convection Condensation

The numerical analysis is made for free-convection condensation of binary vapor mixtures quite similarly as the case of forced-convection condensation. The physical properties which are evaluated at the arithmetic mean of the mass concentrations at the vapor-liquid interface and the bulk and the corresponding saturation temperature are recommended as the representative ones in the case of the algebraic solution

Representative Physical Properties for the Vapor Boundary Layer in the Case of Laminar Film Condensation of Binary Vapor Mixtures : (I) Forced-Convection Condensation

The two-phase boundary layer equations for forced-convection condensation of binary vapor mixtures air-water and ethanol-water are numerically solved under the assumption that the physical properties in the vapor phase depend on mass concentration and temperature and those in the condensate film are constant. The results for wall heat flux and concentration mass flux agree well with the solutions of the author\u27s algebraic equations when the physical properties are evaluated at the arithmetic mean of the mass concentration at the vapor-liquid interface and the bulk and the corresponding saturation temperature, or evaluated at the arithmetic means of the mass concentration and temperature at the vapor-liquid interface and the bulk, and agree with the arithmetic mean values of the wall heat flux and concentration mass flux which are solved by using the physical properties evaluated at the vapor-liquid interface and the bulk

Dental check-up for adults in a community as an effective means to early dental treatment

本論文の要旨は平成7年9月の第34回広島県歯科医学会において発表した